Alpha-Amino-Beta-Carboxy-Muconate-Semialdehyde Decarboxylase Controls Dietary Niacin Requirements for NAD+ Synthesis
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منابع مشابه
Structural and Mechanistic Studies on α-Amino β- Carboxymuconate ε-Semialdehyde Decarboxylase and α-Aminomuconate ε-Semialdehyde Dehydrogenase
α-Amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) and αaminomuconate-ε-semialdehyde dehydrogenase (AMSDH) are two neighboring enzymes in the L-tryptophan and 2-nitrobenzoic acid degradation pathways. The substrates of the two enzymes, α-amino-β-carboxymuconate-ε-semialdehyde (ACMS) and α-aminomuconate-ε-semialdehyde (2-AMS), are unstable and spontaneously decay to quinolinic acid a...
متن کاملPurification and molecular cloning of rat 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase.
2-Amino-3-carboxymuconate-6-semialdehyde decarboxylase (ACMSD; EC 4.1.1.45) is one of the important enzymes regulating tryptophan-niacin metabolism. In the present study, we purified the enzyme from rat liver and kidney, and cloned the cDNA encoding rat ACMSD. The molecular masses of rat ACMSDs purified from the liver and kidney were both estimated to be 39 kDa by SDS/PAGE. Analysis of N-termin...
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Catabolism of Trp and Lys produces alpha-ketoadipic acid as an intermediary metabolite. An alternate pathway of Trp turnover leads to NAD synthesis. We hypothesized that excess Lys might improve the conversion of Trp to niacin by causing a buildup of alpha-ketoadipic acid, thereby endproduct inhibiting the main Trp catabolic pathway and resulting in more niacin synthesis from Trp. Six bioassays...
متن کاملOne Pot Synthesis of Alpha-Aminonitrile and Alpha-Amino Acid From Schiff Bases
Addition of Potassium cyanide to a mixture of Schiff base and lithium perchlorate afforded a-aminonitriles in high yields. Addition of potassium cyanide to a methanolic solution of Schiff base and phosphoric acid afforded a-aminonitriles. When the reaction mixture was refluxed it gave a-amino acids in high yields.
متن کاملAntidepressants may lead to a decrease in niacin and NAD in patients with poor dietary intake.
The term niacin is the generic name for the two compounds nicotinic acid and nicotinamide, the major dietary precursors for two important coenzymes, nicotinamide adenine dinucleotide (NAD) and its phosphorylated form, NADP. Niacin is important for the maintenance of cellular integrity and energy production and is involved in more than 500 intracellular reactions. Deficiencies of niacin may cont...
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ژورنال
عنوان ژورنال: Cell Reports
سال: 2018
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2018.09.091